Title : Bioconversion of deoxypodophyllotoxin into epipodophyllotoxin in E. coli using human cytochrome P450 3A4.

Pub. Date : 2006 Nov 10

PMID : 16753237






1 Functional Relationships(s)
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1 The CYP3A4 enzyme shows a distinctly different reactivity to deoxypodophyllotoxin compared to the semi-synthetic derivatives etoposide and teniposide, which are degraded by 3-O-demethylation. Etoposide cytochrome P450 family 3 subfamily A member 4 Homo sapiens