Title : Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion.

Pub. Date : 2006 Aug 4

PMID : 16740637






2 Functional Relationships(s)
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1 We have previously reported that glucose-stimulated insulin secretion (GSIS) is tightly correlated with pyruvate carboxylase (PC)-catalyzed anaplerotic flux into the tricarboxylic acid cycle and stimulation of pyruvate cycling activity. Pyruvic Acid pyruvate carboxylase Rattus norvegicus
2 We conclude that beta-cells activate compensatory mechanisms in response to suppression of PC expression that prevent impairment of anaplerosis, pyruvate cycling, NAPDH production, and GSIS. Pyruvic Acid pyruvate carboxylase Rattus norvegicus