Title : [Downregulation of Bcl-2 and survivin expression and release of Smac/DIABLO involved in bufalin-induced HL-60 cell apoptosis].

Pub. Date : 2006 Jan

PMID : 16732934






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 OBJECTIVE: To investigate the expression of mitochondria-mediated apoptosis pathway related genes bcl-2, Bax, survivin and Smac/DIABLO in bufalin induced HL-60 cell apoptosis. bufalin BCL2 apoptosis regulator Homo sapiens
2 The active subunits of caspase-3 were displayed after treatment for 8 h till 48 h. CONCLUSION: Apoptosis induced by bufalin is related to downregulation of expressions of bcl-2 and survivin, decrease of Bcl-2/Bax ratio, mitochondrial release of Smac/DIABLO, and activation of caspase-3. bufalin BCL2 apoptosis regulator Homo sapiens
3 The active subunits of caspase-3 were displayed after treatment for 8 h till 48 h. CONCLUSION: Apoptosis induced by bufalin is related to downregulation of expressions of bcl-2 and survivin, decrease of Bcl-2/Bax ratio, mitochondrial release of Smac/DIABLO, and activation of caspase-3. bufalin BCL2 apoptosis regulator Homo sapiens