Pub. Date : 2006 Nov 9
PMID : 16732321
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | In patients with medullary thyroid carcinoma (MTC) and type 2A multiple endocrine neoplasia (MEN2A), mutations of cysteine residues in the extracellular juxtamembrane region of the RET receptor tyrosine kinase cause the formation of covalent receptor dimers linked by intermolecular disulfide bonds between unpaired cysteines, followed by oncogenic activation of the RET kinase. | Disulfides | ret proto-oncogene | Homo sapiens |
2 | In patients with medullary thyroid carcinoma (MTC) and type 2A multiple endocrine neoplasia (MEN2A), mutations of cysteine residues in the extracellular juxtamembrane region of the RET receptor tyrosine kinase cause the formation of covalent receptor dimers linked by intermolecular disulfide bonds between unpaired cysteines, followed by oncogenic activation of the RET kinase. | Disulfides | ret proto-oncogene | Homo sapiens |