Title : Self-association of the transmembrane domain of RET underlies oncogenic activation by MEN2A mutations.

Pub. Date : 2006 Nov 9

PMID : 16732321






2 Functional Relationships(s)
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1 In patients with medullary thyroid carcinoma (MTC) and type 2A multiple endocrine neoplasia (MEN2A), mutations of cysteine residues in the extracellular juxtamembrane region of the RET receptor tyrosine kinase cause the formation of covalent receptor dimers linked by intermolecular disulfide bonds between unpaired cysteines, followed by oncogenic activation of the RET kinase. Disulfides ret proto-oncogene Homo sapiens
2 In patients with medullary thyroid carcinoma (MTC) and type 2A multiple endocrine neoplasia (MEN2A), mutations of cysteine residues in the extracellular juxtamembrane region of the RET receptor tyrosine kinase cause the formation of covalent receptor dimers linked by intermolecular disulfide bonds between unpaired cysteines, followed by oncogenic activation of the RET kinase. Disulfides ret proto-oncogene Homo sapiens