Title : Agents which reverse multidrug-resistance are inhibitors of [3H]vinblastine transport by isolated vesicles.

Pub. Date : 1991 Jan 9

PMID : 1671642






1 Functional Relationships(s)
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1 Resistance of human cancer cells to multiple cytotoxic hydrophobic agents (multidrug resistance) is due to overexpression of the MDR1 gene whose product is the ATP-dependent multidrug transporter, P-glycoprotein. Adenosine Triphosphate ATP binding cassette subfamily B member 1 Homo sapiens