Pub. Date : 2006 May 15
PMID : 16707465
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | c-Jun NH(2)-terminal kinase signaling axis regulates diallyl trisulfide-induced generation of reactive oxygen species and cell cycle arrest in human prostate cancer cells. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Using DU145 and PC-3 human prostate cancer cells as a model, we now report a novel mechanism involving c-Jun NH(2)-terminal kinase (JNK) signaling axis, which is known for its role in regulation of cell survival and apoptosis, in DATS-induced ROS production. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Using DU145 and PC-3 human prostate cancer cells as a model, we now report a novel mechanism involving c-Jun NH(2)-terminal kinase (JNK) signaling axis, which is known for its role in regulation of cell survival and apoptosis, in DATS-induced ROS production. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Interestingly, DATS-mediated degradation of ferritin, increase in labile iron pool, ROS generation, and/or cell cycle arrest were significantly attenuated by ectopic expression of a catalytically inactive mutant of JNK kinase 2 and RNA interference of stress-activated protein kinase/extracellular signal-regulated kinase 1 (SEK1), upstream kinases in JNK signal transduction pathway. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | In conclusion, the present study provides experimental evidence to indicate existence of a novel pathway involving JNK signaling axis in regulation of DATS-induced ROS generation. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |