Pub. Date : 2006 Oct
PMID : 16705148
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Maintaining the cells in thiamin-deficient medium led to a significant (P < 0.01) and specific upregulation in [(3)H]thiamin uptake, which was associated with an increase in hTHTR-1 and hTHTR-2 protein and mRNA levels as well as promoter activities. | Thiamine | solute carrier family 19 member 3 | Homo sapiens |
| 2 | Maintaining the cells in thiamin-deficient medium led to a significant (P < 0.01) and specific upregulation in [(3)H]thiamin uptake, which was associated with an increase in hTHTR-1 and hTHTR-2 protein and mRNA levels as well as promoter activities. | Thiamine | solute carrier family 19 member 3 | Homo sapiens |
| 3 | These studies demonstrate for the first time that thiamin uptake by HEK-293 cells is mediated via a specific pH-dependent process, which involves both the hTHTR-1 and hTHTR-2. | Thiamine | solute carrier family 19 member 3 | Homo sapiens |
| 4 | In addition, the uptake process appears to be under the regulation of an intracellular Ca(2+)/CaM-mediated pathway and also adaptively upregulated in thiamin deficiency via transcriptional regulatory mechanism(s) that involves both the hTHTR-1 and hTHTR-2. | Thiamine | solute carrier family 19 member 3 | Homo sapiens |