Title : The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol.

Pub. Date : 2006 May 23

PMID : 16700548






1 Functional Relationships(s)
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1 On the basis of the comparison of the NQO1 structure in complex with different NQO1 inhibitors and our previous analysis of NQO1 mutants, we propose that the specific conformation of Tyr 128 and Phe 232 is important for NQO1 interaction with p53 and other client proteins. Tyrosine tumor protein p53 Homo sapiens