Title : p38 and ERK MAP kinase mediates iron chelator-induced apoptosis and -suppressed differentiation of immortalized and malignant human oral keratinocytes.

Pub. Date : 2006 Sep 5

PMID : 16697418






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 DFO strongly activates p38 MAP kinase and extracellular signal-regulated kinase (ERK), but does not activate c-Jun N-terminal kinase/stress-activated protein kinase. Deferoxamine mitogen-activated protein kinase 14 Homo sapiens
2 DFO suppressed the expression of epithelial differentiation markers such as involucrin, CK6, and CK19, and this suppression was blocked by p38 and ERK MAP kinase inhibitors. Deferoxamine mitogen-activated protein kinase 14 Homo sapiens