Title : Isolation and properties of the CYP2D25 promoter: transcriptional regulation by vitamin D3 metabolites.

Pub. Date : 2006 Jun 30

PMID : 16690021






3 Functional Relationships(s)
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1 The promoter activity was markedly suppressed by 1alpha,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in presence of vitamin D receptor (VDR). Calcifediol vitamin D receptor Homo sapiens
2 The promoter activity was markedly suppressed by 1alpha,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in presence of vitamin D receptor (VDR). Calcifediol vitamin D receptor Homo sapiens
3 The data suggest that VDR-mediated inhibition of 25-hydroxylase(s) by vitamin D3 metabolites at the transcriptional level may play an important role in the regulation of 25-hydroxyvitamin D3 production in liver and other tissues. Calcifediol vitamin D receptor Homo sapiens