Title : Human melanoma targeting with alpha-MSH-melphalan conjugate.

Pub. Date : 1991 Jun-Jul

PMID : 1668532






3 Functional Relationships(s)
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1 Human melanoma targeting with alpha-MSH-melphalan conjugate. Melphalan proopiomelanocortin Homo sapiens
2 alpha-MSH receptor recognition properties also remained unchanged with a better apparent affinity of the conjugate probably due to the alkylating activity of melphalan itself. Melphalan proopiomelanocortin Homo sapiens
3 Using human melanoma dendritic cells expressing more than 10,000 alpha-MSH binding sites per cell as an in vitro model, we were able to demonstrate higher cytotoxicities as compared to melphalan-treated cells. Melphalan proopiomelanocortin Homo sapiens