Title : The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.

Pub. Date : 2006 May 16

PMID : 16684881






2 Functional Relationships(s)
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1 Because of their bone-selective pharmacokinetics, nitrogen-containing bisphosphonates (N-BPs), currently used as clinical inhibitors of bone-resorption diseases, target osteoclast farnesyl pyrophosphate synthase (FPPS) and inhibit protein prenylation. Diphosphonates farnesyl diphosphate synthase Homo sapiens
2 Because of their bone-selective pharmacokinetics, nitrogen-containing bisphosphonates (N-BPs), currently used as clinical inhibitors of bone-resorption diseases, target osteoclast farnesyl pyrophosphate synthase (FPPS) and inhibit protein prenylation. Diphosphonates farnesyl diphosphate synthase Homo sapiens