Title : Topoisomerase IIalpha gene amplification predicts favorable treatment response to tailored and dose-escalated anthracycline-based adjuvant chemotherapy in HER-2/neu-amplified breast cancer: Scandinavian Breast Group Trial 9401.

Pub. Date : 2006 Jun 1

PMID : 16682728






2 Functional Relationships(s)
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1 PURPOSE: Amplification of the HER-2/neu and topoisomerase IIalpha (TOP2A) genes has been linked to the effects of anthracyclines. Anthracyclines DNA topoisomerase II alpha Homo sapiens
2 CONCLUSION: Coamplification of HER-2/neu and TOP2A may define a subgroup of high-risk breast cancer patients who benefit from individually tailored and dose-escalated adjuvant anthracyclines. Anthracyclines DNA topoisomerase II alpha Homo sapiens