Title : Loss of function polymorphisms in NAT1 protect against spina bifida.

Pub. Date : 2006 Aug

PMID : 16680433






5 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 N-acetyltransferase 1 (NAT1) participates in the catabolism of folates and the acetylation of aromatic and heterocyclic amines. Folic Acid N-acetyltransferase 1 Homo sapiens
2 N-acetyltransferase 1 (NAT1) participates in the catabolism of folates and the acetylation of aromatic and heterocyclic amines. Folic Acid N-acetyltransferase 1 Homo sapiens
3 Hence, functional polymorphisms in NAT1, the gene encoding NAT1, could influence the risk of spina bifida via either folate catabolism or acetylation of exogenous agents. Folic Acid N-acetyltransferase 1 Homo sapiens
4 Hence, functional polymorphisms in NAT1, the gene encoding NAT1, could influence the risk of spina bifida via either folate catabolism or acetylation of exogenous agents. Folic Acid N-acetyltransferase 1 Homo sapiens
5 These associations may be attributable to a decrease in either folate catabolism or the conversion of exogenous agents to teratogenic derivatives in women and/or developing embryos with a NAT1 genotype that includes a loss of function allele relative to those who do not. Folic Acid N-acetyltransferase 1 Homo sapiens