Title : ACTH secretion from mouse pituitary tumor cells is inhibited by loop diuretic drugs.

Pub. Date : 1991 Oct 14

PMID : 1666052






3 Functional Relationships(s)
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1 Forskolin did not affect the activity of the Na+/K+/Cl- co-transporter but both basal and forskolin-stimulated secretion of ACTH were inhibited by furosemide (IC50 of 5 x 10(-4) M; maximal inhibition: 50%). Colforsin pro-opiomelanocortin-alpha Mus musculus
2 Forskolin did not affect the activity of the Na+/K+/Cl- co-transporter but both basal and forskolin-stimulated secretion of ACTH were inhibited by furosemide (IC50 of 5 x 10(-4) M; maximal inhibition: 50%). Colforsin pro-opiomelanocortin-alpha Mus musculus
3 Use of cyclamate or gluconate in place of Cl- also resulted in the inhibition of basal and forskolin-stimulated ACTH secretion. Colforsin pro-opiomelanocortin-alpha Mus musculus