Title : Calcitonin gene-related peptide (CGRP)-induced cyclic AMP, cyclic GMP and vasorelaxant responses in rat thoracic aorta are antagonized by blockers of endothelium-derived relaxant factor (EDRF).

Pub. Date : 1991 Oct

PMID : 1665896






2 Functional Relationships(s)
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1 Both CGRP- and ACh-induced relaxations of aorta were significantly inhibited by the EDRF blocking agents, hemoglobin (10 microM), methylene blue (10 microM), and nordihydroguaiaretic acid (NDGA, 10 microM). Methylene Blue calcitonin-related polypeptide alpha Rattus norvegicus
2 Hemoglobin, methylene blue and NDGA also inhibited the CGRP-induced increases in both cyclic AMP and cyclic GMP levels. Methylene Blue calcitonin-related polypeptide alpha Rattus norvegicus