Pub. Date : 2006 May-Jun
PMID : 16647867
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Retinoic acid-induced protein ISGylation is dependent on interferon signal transduction. | Tretinoin | interferon alpha 1 | Homo sapiens |
| 2 | It was recently demonstrated that ISG15 expression, ISG15 conjugation, and several enzymes involved in ISG15 modification are upregulated in an acute promyelocytic cell line following treatment with retinoic acid, suggesting a possible retinoic acid induced IFN-independent ISG15 modification pathway. | Tretinoin | interferon alpha 1 | Homo sapiens |
| 3 | It was recently demonstrated that ISG15 expression, ISG15 conjugation, and several enzymes involved in ISG15 modification are upregulated in an acute promyelocytic cell line following treatment with retinoic acid, suggesting a possible retinoic acid induced IFN-independent ISG15 modification pathway. | Tretinoin | interferon alpha 1 | Homo sapiens |
| 4 | In this study, we examined a possible link between IFN signaling and retinoic acid-induced ISG15 conjugation. | Tretinoin | interferon alpha 1 | Homo sapiens |
| 5 | By sandwich ELISA, we detected increased IFN secretion into cell culture media following retinoic acid treatment. | Tretinoin | interferon alpha 1 | Homo sapiens |
| 6 | Blockade of the type I IFN receptor with a neutralizing antibody blocked retinoic acid induced ISG15 expression and ISG15 conjugation. | Tretinoin | interferon alpha 1 | Homo sapiens |
| 7 | Taken together, these data suggested that retinoic acid-induced secretion of IFN plays a fundamental role in retinoic acid promoted ISGylation. | Tretinoin | interferon alpha 1 | Homo sapiens |
| 8 | Taken together, these data suggested that retinoic acid-induced secretion of IFN plays a fundamental role in retinoic acid promoted ISGylation. | Tretinoin | interferon alpha 1 | Homo sapiens |