Pub. Date : 2006 May 23
PMID : 16647690
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | There was a significant decrease in binding of the specific GABABR antagonist, [3H]CGP-54626A at postnatal day (PN)7 and PN14 in SSADH(-/-) when compared to wild type control animals (SSADH(+/+)), particularly in hippocampus. | gababr | aldehyde dehydrogenase 5 family member A1 | Homo sapiens |
| 2 | There was a significant decrease in binding of the specific GABABR antagonist, [3H]CGP-54626A at postnatal day (PN)7 and PN14 in SSADH(-/-) when compared to wild type control animals (SSADH(+/+)), particularly in hippocampus. | gababr | aldehyde dehydrogenase 5 family member A1 | Homo sapiens |
| 3 | GABABR-mediated synaptic potentials were decreased in SSADH(-/-). | gababr | aldehyde dehydrogenase 5 family member A1 | Homo sapiens |
| 4 | These data suggest that the elevated levels of GABA and GHB that occur in SSADH(-/-) lead to a use-dependent decrease in GABABR-mediated function and raise the possibility that this GHB- and GABA-induced perturbation of GABABR could play a role in the pathogenesis of the seizures and mental retardation observed in SSADH deficiency. | gababr | aldehyde dehydrogenase 5 family member A1 | Homo sapiens |
| 5 | These data suggest that the elevated levels of GABA and GHB that occur in SSADH(-/-) lead to a use-dependent decrease in GABABR-mediated function and raise the possibility that this GHB- and GABA-induced perturbation of GABABR could play a role in the pathogenesis of the seizures and mental retardation observed in SSADH deficiency. | gababr | aldehyde dehydrogenase 5 family member A1 | Homo sapiens |