Title : The adaptive filter of the yeast galactose pathway.

Pub. Date : 2006 Sep 21

PMID : 16643954






4 Functional Relationships(s)
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1 In the yeast Saccharomyces cerevisiae, the interplay between galactose, Gal3p, Gal80p and Gal4p determines the transcriptional status of the genes required for galactose utilization. Galactose transcriptional regulator GAL3 Saccharomyces cerevisiae S288C
2 After an increase in galactose concentration, galactose molecules bind onto Gal3p. Galactose transcriptional regulator GAL3 Saccharomyces cerevisiae S288C
3 After an increase in galactose concentration, galactose molecules bind onto Gal3p. Galactose transcriptional regulator GAL3 Saccharomyces cerevisiae S288C
4 Here we propose a qualitative dynamical model, whereby these molecular interaction events represent the first two stages of a functional feedback loop that closes with the capture of activated Gal4p by newly synthesized Gal3p and Gal80p, decreasing transcriptional activation and creating again the protein complex that can bind incoming galactose molecules. Galactose transcriptional regulator GAL3 Saccharomyces cerevisiae S288C