Pub. Date : 2006 Jun 7
PMID : 16642033
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In transfected cells and isolated mitochondria, Bcl-2, but not the inactive point mutants Bcl-2-G145A and Bcl-2-V159D, undergoes a conformation change in the mitochondrial membrane in response to apoptotic agonists such as tBid and Bax. | tBID | BCL2 apoptosis regulator | Homo sapiens |
| 2 | Thus, Bcl-2 must change the conformation to inhibit tBid-induced oligomerization of integral membrane Bax monomers and small oligomers. | tBID | BCL2 apoptosis regulator | Homo sapiens |