Title : Therapy of organophosphate poisoning in the rat by direct effects of oximes unrelated to ChE reactivation.

Pub. Date : 1991

PMID : 1664202






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Isolated rat diaphragm preparations treated with soman or with the irreversible and oxime resistant cholinesterase (ChE) inhibitor S27 showed a considerable recovery of neuromuscular transmission (NMT) during incubation with the (bis)pyridinium oximes HI-6, HGG-12, P2S and obidoxime. Oximes butyrylcholinesterase Rattus norvegicus
2 Isolated rat diaphragm preparations treated with soman or with the irreversible and oxime resistant cholinesterase (ChE) inhibitor S27 showed a considerable recovery of neuromuscular transmission (NMT) during incubation with the (bis)pyridinium oximes HI-6, HGG-12, P2S and obidoxime. Oximes butyrylcholinesterase Rattus norvegicus
3 Atropinized rats were artificially ventilated after injection with 3 x LD50 soman for 3 h and then treated with HI-6, i.e. at a time when oxime reactivation of soman inhibited ChE is no longer possible. Oximes butyrylcholinesterase Rattus norvegicus