Title : Critical involvement of IL-12 in IFN-gamma induction by calcineurin antagonists in activated human lymphocytes.

Pub. Date : 2006 Jul

PMID : 16641133






6 Functional Relationships(s)
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1 Here, we show that calcineurin antagonists such as cyclosporin A (CsA) or tacrolimus can markedly enhance the production of interferon-gamma (IFN-gamma) by human T cells. Cyclosporine interferon gamma Homo sapiens
2 Here, we show that calcineurin antagonists such as cyclosporin A (CsA) or tacrolimus can markedly enhance the production of interferon-gamma (IFN-gamma) by human T cells. Cyclosporine interferon gamma Homo sapiens
3 Here, we show that calcineurin antagonists such as cyclosporin A (CsA) or tacrolimus can markedly enhance the production of interferon-gamma (IFN-gamma) by human T cells. Cyclosporine interferon gamma Homo sapiens
4 Here, we show that calcineurin antagonists such as cyclosporin A (CsA) or tacrolimus can markedly enhance the production of interferon-gamma (IFN-gamma) by human T cells. Cyclosporine interferon gamma Homo sapiens
5 IL-27, which could mimic the effect of IL-12, was however less potent in inducing IFN-gamma production in the presence of CsA and TCR stimulation. Cyclosporine interferon gamma Homo sapiens
6 CsA-dependent IFN-gamma production is observable in therapeutic concentrations. Cyclosporine interferon gamma Homo sapiens