Title : A zinc-binding region in Vif binds Cul5 and determines cullin selection.

Pub. Date : 2006 Jun 23

PMID : 16636053






1 Functional Relationships(s)
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1 Mutations of conserved hydrophobic residues (Ile-120, Ala-123, and Leu-124) located between the two Cys residues in the HCCH motif disrupt binding of the zinc-coordinating region to Cul5 and inhibit APOBEC3G degradation. Isoleucine apolipoprotein B mRNA editing enzyme catalytic subunit 3G Homo sapiens