Title : Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade.

Pub. Date : 2006 May

PMID : 16635021






2 Functional Relationships(s)
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1 Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade. Melatonin mitogen-activated protein kinase 3 Homo sapiens
2 Further characterization of the mechanisms underlying melatonin"s effects on these differentiation processes revealed that MEK (1/2) and ERK (1/2), epidermal growth factor receptors, metalloproteinase and clathrin-mediated endocytosis were essential while PKA was not. Melatonin mitogen-activated protein kinase 3 Homo sapiens