Pub. Date : 2006 May 1
PMID : 16632111
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DFO rapidly phosphorylated both extracellular signal-regulated kinase (ERK) and p38 kinase. | Deferoxamine | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | DFO rapidly phosphorylated both extracellular signal-regulated kinase (ERK) and p38 kinase. | Deferoxamine | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | DFO rapidly phosphorylated both extracellular signal-regulated kinase (ERK) and p38 kinase. | Deferoxamine | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Blockade of ERK signaling by the MEK1/2 inhibitor PD098059 abolished DFO-induced class A scavenger receptor (SR-A) expression and phagocytic activity, indicating that ERK cascades mediate the induction of THP-1 differentiation. | Deferoxamine | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | Blockade of ERK signaling by the MEK1/2 inhibitor PD098059 abolished DFO-induced class A scavenger receptor (SR-A) expression and phagocytic activity, indicating that ERK cascades mediate the induction of THP-1 differentiation. | Deferoxamine | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | In contrast, in cells treated with the p38 inhibitor SB203580 or transfected with the dominant-negative variant of p38 kinase, DFO-mediated ERK activation became more prominent, and the induction of SR-A expression and phagocytic activity were significantly increased. | Deferoxamine | mitogen-activated protein kinase 1 | Homo sapiens |
| 7 | In contrast, in cells treated with the p38 inhibitor SB203580 or transfected with the dominant-negative variant of p38 kinase, DFO-mediated ERK activation became more prominent, and the induction of SR-A expression and phagocytic activity were significantly increased. | Deferoxamine | mitogen-activated protein kinase 1 | Homo sapiens |
| 8 | In contrast, in cells treated with the p38 inhibitor SB203580 or transfected with the dominant-negative variant of p38 kinase, DFO-mediated ERK activation became more prominent, and the induction of SR-A expression and phagocytic activity were significantly increased. | Deferoxamine | mitogen-activated protein kinase 1 | Homo sapiens |
| 9 | Collectively, these results indicate that oxidative stress by DFO and the resulting activation of ERK cascade play dominant roles in the process of THP-1 differentiation, while p38 acts as a negative signal transmitter. | Deferoxamine | mitogen-activated protein kinase 1 | Homo sapiens |