Pub. Date : 2006 Apr 15
PMID : 16631521
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Heme oxygenase-1 contributes to the cytoprotection of alpha-lipoic acid via activation of p44/42 mitogen-activated protein kinase in vascular smooth muscle cells. | Thioctic Acid | heme oxygenase 1 | Homo sapiens |
| 2 | ALA significantly induced HO-1 expression accompanied by an increase in HO activity in A10 cells. | Thioctic Acid | heme oxygenase 1 | Homo sapiens |
| 3 | ALA significantly increased ROS, and this effect was blocked by N-acetyl-cysteine, which also inhibited ALA-induced activation of p44/42 mitogen-activated protein kinase (MAPK) and AP-1, HO-1 expression, and HO activity. | Thioctic Acid | heme oxygenase 1 | Homo sapiens |
| 4 | ALA significantly increased ROS, and this effect was blocked by N-acetyl-cysteine, which also inhibited ALA-induced activation of p44/42 mitogen-activated protein kinase (MAPK) and AP-1, HO-1 expression, and HO activity. | Thioctic Acid | heme oxygenase 1 | Homo sapiens |
| 5 | These results suggest that ALA induces HO-1 expression through the production of ROS and subsequent activation of the p44/42 MAPK pathway and AP-1 in vascular smooth muscle cells. | Thioctic Acid | heme oxygenase 1 | Homo sapiens |
| 6 | This study demonstrated that ALA increases the expression of HO-1, a critical cytoprotective molecule, and identified a novel pleiotropic effect of ALA on cardiovascular protection. | Thioctic Acid | heme oxygenase 1 | Homo sapiens |