Title : Opposite effects of phospholipase A2 on [3H]AMPA binding in adult and neonatal membranes.

Pub. Date : 1991 Aug 19

PMID : 1661214






6 Functional Relationships(s)
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1 Opposite effects of phospholipase A2 on [3H]AMPA binding in adult and neonatal membranes. Tritium phospholipase A2 group IB Rattus norvegicus
2 In the present study, we compared the effect of phospholipase A2 (PLA2) treatment of synaptic membranes from adult and neonatal rats on the characteristics of [3H]AMPA binding sites. Tritium phospholipase A2 group IB Rattus norvegicus
3 In the present study, we compared the effect of phospholipase A2 (PLA2) treatment of synaptic membranes from adult and neonatal rats on the characteristics of [3H]AMPA binding sites. Tritium phospholipase A2 group IB Rattus norvegicus
4 Whereas PLA2 treatment of membranes from adult rats produces an increased affinity for [3H]AMPA binding, the same treatment in neonatal rats results in a decrease in the maximal number of binding sites. Tritium phospholipase A2 group IB Rattus norvegicus
5 Since activation of PLA2 has been proposed to play a critical role in the formation of long-term potentiation (LTP), possibly mediated through a modification of the AMPA receptors, the results strengthen the hypothesis that PLA2-induced modification of [3H]AMPA binding sites is an important component of synaptic plasticity. Tritium phospholipase A2 group IB Rattus norvegicus
6 Since activation of PLA2 has been proposed to play a critical role in the formation of long-term potentiation (LTP), possibly mediated through a modification of the AMPA receptors, the results strengthen the hypothesis that PLA2-induced modification of [3H]AMPA binding sites is an important component of synaptic plasticity. Tritium phospholipase A2 group IB Rattus norvegicus