Title : Poly I:C-induced anti-herpes simplex virus type 1 activity in inflammatory macrophages is mediated by induction of interferon-beta.

Pub. Date : 1991 Nov

PMID : 1660913






3 Functional Relationships(s)
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1 Poly I:C-induced anti-herpes simplex virus type 1 activity in inflammatory macrophages is mediated by induction of interferon-beta. Poly I-C interferon beta 1 Homo sapiens
2 In addition, we demonstrate that supernatants from macrophages treated with Poly I:C contain IFN-beta but not IFN-alpha. Poly I-C interferon beta 1 Homo sapiens
3 Taken together these data indicate that the antiviral effects of Poly I:C in inflammatory macrophages are mediated solely by IFN-beta, which acts in an autocrine manner to induce resistance to HSV-1. Poly I-C interferon beta 1 Homo sapiens