Title : Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.

Pub. Date : 2006 Jul

PMID : 16608920






2 Functional Relationships(s)
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1 Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. Miconazole nuclear receptor subfamily 3 group C member 1 Homo sapiens
2 In the current study, we investigated the effect of ketoconazole and other azole-derived drugs, miconazole and fluconazole, on the transcriptional activity of the human GR (hGR) in HeLa and HepG2 cells, and in primary human hepatocytes. Miconazole nuclear receptor subfamily 3 group C member 1 Homo sapiens