Title : PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells.

Pub. Date : 2006 Jun 9

PMID : 16608847






2 Functional Relationships(s)
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1 We found that Bcl-X(L) was most effective among several antiapoptotic proteins in suppressing PUMA-induced apoptosis and PUMA-dependent apoptosis induced by the DNA-damaging agent adriamycin. Doxorubicin BCL2 like 1 Homo sapiens
2 Furthermore, Bax was found to be dissociated preferentially from Bcl-X(L) in HCT116 cells but not in the PUMA-knockout cells, in response to PUMA induction and adriamycin treatment. Doxorubicin BCL2 like 1 Homo sapiens