Title : The novel antidepressant, tianeptine, reduces stress-evoked stimulation of the hypothalamo-pituitary-adrenal axis.

Pub. Date : 1991 Sep 24

PMID : 1660816






3 Functional Relationships(s)
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1 injection of tianeptine (10 mg/kg), 120 min before stress caused a significant decrease of ACTH and corticosterone levels. tianeptine proopiomelanocortin Homo sapiens
2 The inhibitory effect of tianeptine on stress-induced elevations of plasma ACTH and corticosterone occurred from 1 to 3 h after the injection. tianeptine proopiomelanocortin Homo sapiens
3 Administration of increasing doses of tianeptine revealed that only the highest doses (10 and 20 mg/kg) had a significant effect on stress-evoked stimulation of ACTH and corticosterone secretion. tianeptine proopiomelanocortin Homo sapiens