Pub. Date : 2006 Apr
PMID : 16608165
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oxidative deboronation of the peptide boronic acid proteasome inhibitor bortezomib: contributions from reactive oxygen species in this novel cytochrome P450 reaction. | Reactive Oxygen Species | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | Chemically generated reactive oxygen species (ROS), such as those generated as byproducts during P450 catalysis, were also found to deboronate 1 resulting in the formation of M1 and M2. | Reactive Oxygen Species | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | Chemically generated reactive oxygen species (ROS), such as those generated as byproducts during P450 catalysis, were also found to deboronate 1 resulting in the formation of M1 and M2. | Reactive Oxygen Species | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | The presence of superoxide dismutase (SOD) and catalase prevented the deboronation of 1, thus, supporting the involvement of ROS in the P450 2E1-catalyzed deboronation reaction. | Reactive Oxygen Species | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | Our present findings indicate that the oxidase activity of P450 (i.e., formation of ROS) represents a mechanism of deboronation. | Reactive Oxygen Species | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |