Title : The active site of thrombin is altered upon binding to thrombomodulin. Two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation.

Pub. Date : 1991 Dec 5

PMID : 1660464






1 Functional Relationships(s)
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1 The environments of the fluorescein and ANS dyes were also altered when GF1-6 bound to thrombin because binding resulted in emission intensity changes of -13% and +18%, respectively. Fluorescein coagulation factor II, thrombin Homo sapiens