Pub. Date : 2006 Jun
PMID : 16604092
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rosmarinic acid as a downstream inhibitor of IKK-beta in TNF-alpha-induced upregulation of CCL11 and CCR3. | rosmarinic acid | tumor necrosis factor | Homo sapiens |
| 2 | In order to determine the effects of rosmarinic acid on the TNF-alpha-induced upregulation of CCL11 and CCR3 in human dermal fibroblasts, we performed an enzyme-linked immunosorbent assay for CCL11 and a Western blot assay for CCR3. | rosmarinic acid | tumor necrosis factor | Homo sapiens |
| 3 | The TNF-alpha-induced expression of CCL11 and CCR3 genes was attenuated by rosmarinic acid. | rosmarinic acid | tumor necrosis factor | Homo sapiens |
| 4 | In our NF-kappaB luciferase reporter system, TNF-alpha-induced NF-kappaB activation was observed to be reduced by rosmarinic acid. | rosmarinic acid | tumor necrosis factor | Homo sapiens |
| 5 | In accordance with this result, rosmarinic acid also inhibited TNF-alpha-induced phosphorylation and degradation of IkappaB-alpha, as well as nuclear translocation of NF-kappaB heterodimer induced by TNF-alpha. | rosmarinic acid | tumor necrosis factor | Homo sapiens |
| 6 | In accordance with this result, rosmarinic acid also inhibited TNF-alpha-induced phosphorylation and degradation of IkappaB-alpha, as well as nuclear translocation of NF-kappaB heterodimer induced by TNF-alpha. | rosmarinic acid | tumor necrosis factor | Homo sapiens |
| 7 | Additionally, TNF-alpha-induced secretion of soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 molecules was found to be attenuated by rosmarinic acid. | rosmarinic acid | tumor necrosis factor | Homo sapiens |