Pub. Date : 2006 Jan
PMID : 16603448
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bcl-2 siRNA induced apoptosis and increased sensitivity to 5-fluorouracil and HCPT in HepG2 cells. | 10-hydroxycamptothecin | BCL2 apoptosis regulator | Homo sapiens |
| 2 | Accordingly, Bax protein expression had no change and caspase-3 protein expression showed significantly be up regulated; (2) MTT results showed that Bcl-2 siRNA transfectants had higher cell inhibitory rates after treated with 5-FU or HCPT; (3) flow cytometry results demonstrated that sub G1 population increased in Bcl-2 siRNA transfected cells compared with negative siRNA or untreated cells. | 10-hydroxycamptothecin | BCL2 apoptosis regulator | Homo sapiens |
| 3 | After addition 5-FU (1300 mg/l) and HCPT (0.72 mg/l), Bcl-2 siRNA cells showed higher sub G1 population than negative siRNA or untreated cells. | 10-hydroxycamptothecin | BCL2 apoptosis regulator | Homo sapiens |
| 4 | siRNA targeting Bcl-2 gene can specifically down-regulate Bcl-2 expression, increased Bax/Bcl-2 ratio expression and caspase-3 activity in HepG2 cells, which lead to increase cells spontaneous apoptosis and sensitize cells to 5-FU or HCPT. | 10-hydroxycamptothecin | BCL2 apoptosis regulator | Homo sapiens |