Title : Relationship between excretion clearance of rhodamine 123 and P-glycoprotein (Pgp) expression induced by representative Pgp inducers.

Pub. Date : 2006 Apr

PMID : 16595917






9 Functional Relationships(s)
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1 Relationship between excretion clearance of rhodamine 123 and P-glycoprotein (Pgp) expression induced by representative Pgp inducers. Rhodamine 123 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
2 Relationship between excretion clearance of rhodamine 123 and P-glycoprotein (Pgp) expression induced by representative Pgp inducers. Rhodamine 123 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
3 Relationship between excretion clearance of rhodamine 123 and P-glycoprotein (Pgp) expression induced by representative Pgp inducers. Rhodamine 123 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
4 In this study, the usefulness of intravenous rhodamine 123 (Rho123) administration as a marker for detecting the inducing effect of Pgp by drugs was identified, and the relationship between excretion clearances of Rho123 via Pgp and its expression during treatment with the representative Pgp inducers rifampicin (RFP), dexamethasone (DEX) and St. John"s Wort (SJW) were examined in rat liver, intestine and kidney. Rhodamine 123 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
5 In this study, the usefulness of intravenous rhodamine 123 (Rho123) administration as a marker for detecting the inducing effect of Pgp by drugs was identified, and the relationship between excretion clearances of Rho123 via Pgp and its expression during treatment with the representative Pgp inducers rifampicin (RFP), dexamethasone (DEX) and St. John"s Wort (SJW) were examined in rat liver, intestine and kidney. Rhodamine 123 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
6 In this study, the usefulness of intravenous rhodamine 123 (Rho123) administration as a marker for detecting the inducing effect of Pgp by drugs was identified, and the relationship between excretion clearances of Rho123 via Pgp and its expression during treatment with the representative Pgp inducers rifampicin (RFP), dexamethasone (DEX) and St. John"s Wort (SJW) were examined in rat liver, intestine and kidney. Rhodamine 123 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
7 In this study, the usefulness of intravenous rhodamine 123 (Rho123) administration as a marker for detecting the inducing effect of Pgp by drugs was identified, and the relationship between excretion clearances of Rho123 via Pgp and its expression during treatment with the representative Pgp inducers rifampicin (RFP), dexamethasone (DEX) and St. John"s Wort (SJW) were examined in rat liver, intestine and kidney. Rhodamine 123 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
8 These observations suggest that the excretion clearances of Rho123 from blood circulation to the small intestine or to the bile after its intravenous administration are useful indicators to assess the Pgp function in the presence of Pgp inducers. Rhodamine 123 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
9 These observations suggest that the excretion clearances of Rho123 from blood circulation to the small intestine or to the bile after its intravenous administration are useful indicators to assess the Pgp function in the presence of Pgp inducers. Rhodamine 123 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus