Title : Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine.

Pub. Date : 2006 Jun 16

PMID : 16595656






1 Functional Relationships(s)
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1 Using confocal microscopy and different truncated and point mutants of hENT1-YFP (yellow fluorescent protein) expressed in Madin-Darby canine kidney cells, we identified amino acid residues Pro(71),Glu(72), and Asn(74) (the PEXN motif) of hENT1 as important in mitochondrial targeting of hENT1. Glutamic Acid solute carrier family 29 member 1 (Augustine blood group) Homo sapiens