Title : Follicle-stimulating hormone increases c-fos mRNA levels in rat granulosa cells via a protein kinase C-dependent mechanism.

Pub. Date : 1991 Sep

PMID : 1659543






2 Functional Relationships(s)
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1 However, tetradecanoyl-13-phorbol acetate (TPA, 200 nM) was able to induce c-fos mRNA expression. Tetradecanoylphorbol Acetate Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 The protein kinase C (PKC) inhibitors H-7 (0.3-30 microM) and staurosporine (0.75 micrograms/ml) blocked FSH-induced c-fos mRNA expression in cultured granulosa cells while HA 1004, an inhibitor of cGMP- and cAMP-dependent protein kinases at 30 microM had no effect on TPA-induced c-fos expression, and only minimally inhibited FSH-induced c-fos expression. Tetradecanoylphorbol Acetate Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus