Title : Capsaicin-induced vasoconstriction in the mouse knee joint: a study using TRPV1 knockout mice.

Pub. Date : 2006 Jun 19

PMID : 16584841






5 Functional Relationships(s)
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1 Capsaicin-induced vasoconstriction in the mouse knee joint: a study using TRPV1 knockout mice. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
2 However, in the present study we have shown that capsaicin produces a dose-dependent vasoconstrictor effect in the mouse knee joint via Transient Receptor Potential Vanilloid 1 (TRPV1) receptor activation. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
3 However, in the present study we have shown that capsaicin produces a dose-dependent vasoconstrictor effect in the mouse knee joint via Transient Receptor Potential Vanilloid 1 (TRPV1) receptor activation. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
4 A (125)I-albumin accumulation technique showed that the intravascular volume of capsaicin-treated joints in wild type (WT) mice was significantly reduced compared to TRPV1 knockout mice (p<0.01). Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
5 Similarly, a laser Doppler technique showed significantly reduced blood flow in the capsaicin-treated joints of WT compared to TRPV1 knockout mice (p<0.001). Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus