Pub. Date : 2006 Apr
PMID : 16584389
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Multidrug resistance 1 genotype and disposition of budesonide in early primary biliary cirrhosis. | Budesonide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | BACKGROUND: Budesonide, which is a dual substrate of P-glycoprotein, the product of the multidrug resistance 1 (MDR1) gene, and cytochrome P450 3A (CYP3A) has been proposed for treatment of early primary biliary cirrhosis (PBC). | Budesonide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | BACKGROUND: Budesonide, which is a dual substrate of P-glycoprotein, the product of the multidrug resistance 1 (MDR1) gene, and cytochrome P450 3A (CYP3A) has been proposed for treatment of early primary biliary cirrhosis (PBC). | Budesonide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | BACKGROUND: Budesonide, which is a dual substrate of P-glycoprotein, the product of the multidrug resistance 1 (MDR1) gene, and cytochrome P450 3A (CYP3A) has been proposed for treatment of early primary biliary cirrhosis (PBC). | Budesonide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | We tested the hypothesis that MDR1 gene polymorphisms affect absorption of oral budesonide. | Budesonide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | RESULTS: In MDR1 2,677 GG and 3,435 CC genotypes, absorption and elimination of budesonide were not significantly different from those in corresponding homozygous variants. | Budesonide | ATP binding cassette subfamily B member 1 | Homo sapiens |