Pub. Date : 2006 May
PMID : 16573780
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Association of -1082 AA low producer IL-10 genotype with steroid dependency. | Steroids | interleukin 10 | Homo sapiens |
2 | In a stratified analysis, a highly significant association between the -1082 AA IL-10 genotype and the steroid dependency was observed in IBD (p < 0.0001), contributing both UC (p = 0.004) and CD (p = 0.003) to this association. | Steroids | interleukin 10 | Homo sapiens |
3 | The steroid-dependent phenotype correlated in UC with extensive disease (p = 0.010) and with the low producer -1082 AA IL-10 genotype (p = 0.002) and in CD with penetrating disease (p = 0.010), arthritis (p = 0.011), and the -1082 AA IL-10 genotype (p = 0.006). | Steroids | interleukin 10 | Homo sapiens |
4 | The steroid-dependent phenotype correlated in UC with extensive disease (p = 0.010) and with the low producer -1082 AA IL-10 genotype (p = 0.002) and in CD with penetrating disease (p = 0.010), arthritis (p = 0.011), and the -1082 AA IL-10 genotype (p = 0.006). | Steroids | interleukin 10 | Homo sapiens |
5 | CONCLUSIONS: The main conclusion is that carriage of the -1082 AA IL-10 genotype (low producer) is a relevant risk factor for developing steroid-dependent IBD. | Steroids | interleukin 10 | Homo sapiens |