Title : Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline.

Pub. Date : 2006 May

PMID : 16573651






1 Functional Relationships(s)
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1 ROT (0.025-0.1 microm) produced a dose-dependent selective reduction of tyrosine hydroxylase-immunoreactive cells and of other neurons, as shown by the immunoreactivity to microtubule-associated protein 2 in PK-KO cultures, suggesting that the toxic effect of ROT involved dopamine and other types of neurons. Tyrosine microtubule-associated protein 2 Mus musculus