Title : Cyclosporine promotes glomerular endothelin binding in vivo.

Pub. Date : 1991 May

PMID : 1657241






2 Functional Relationships(s)
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1 It has previously been shown that administration of cyclosporine causes a prompt (within 15 min after infusion) increase in circulating level of endothelin 1 and a pattern of glomerular hypoperfusion and hypofiltration which can be ameliorated with antiendothelin antibody. Cyclosporine endothelin 1 Rattus norvegicus
2 We now show that 60 min after cyclosporine, serum endothelin 1 level falls to less than 2.55 +/- 0.31 pg/mL (N = 6), a value comparable to that found in normal animals (less than 2 pg/mL). Cyclosporine endothelin 1 Rattus norvegicus