Title : Induction of G2 arrest and binding to cyclophilin A are independent phenotypes of human immunodeficiency virus type 1 Vpr.

Pub. Date : 2006 Apr

PMID : 16571786






5 Functional Relationships(s)
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1 We find that Vpr coimmunoprecipitates with CypA and that this interaction is disrupted by substitution of proline-35 of Vpr as well as incubation with the CypA inhibitor cyclosporine A (CsA). Cyclosporine peptidylprolyl isomerase A Homo sapiens
2 We find that Vpr coimmunoprecipitates with CypA and that this interaction is disrupted by substitution of proline-35 of Vpr as well as incubation with the CypA inhibitor cyclosporine A (CsA). Cyclosporine peptidylprolyl isomerase A Homo sapiens
3 We find that Vpr coimmunoprecipitates with CypA and that this interaction is disrupted by substitution of proline-35 of Vpr as well as incubation with the CypA inhibitor cyclosporine A (CsA). Cyclosporine peptidylprolyl isomerase A Homo sapiens
4 We find that Vpr coimmunoprecipitates with CypA and that this interaction is disrupted by substitution of proline-35 of Vpr as well as incubation with the CypA inhibitor cyclosporine A (CsA). Cyclosporine peptidylprolyl isomerase A Homo sapiens
5 CsA abolished CypA-Vpr binding but had no effect on induction of G2 arrest or Vpr steady-state levels. Cyclosporine peptidylprolyl isomerase A Homo sapiens