Pub. Date : 2006 May 19
PMID : 16569638
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, we investigate the molecular mechanisms involved in the H2O2-mediated induction of MMP-1. | Hydrogen Peroxide | matrix metallopeptidase 1 | Homo sapiens |
| 2 | Mutational analysis of an MMP-1 promoter indicates that both the single nucleotide polymorphism creating an Ets binding site at -1607 and a proximal AP-1 site at -1602 are required for maximal H2O2-dependent transcription. | Hydrogen Peroxide | matrix metallopeptidase 1 | Homo sapiens |
| 3 | Importantly, JNK signaling is largely responsible for the H2O2 sensitivity of the MMP-1 promoter, whereas ERK1/2 contributes to both its basal and H2O2 dependence. | Hydrogen Peroxide | matrix metallopeptidase 1 | Homo sapiens |