Title : Differential involvement of the arachidonic acid cascade on the alpha 1-adrenergic potentiation of vasoactive intestinal peptide- versus beta-adrenergic-stimulated cyclic AMP and cyclic GMP accumulation in rat pinealocytes.

Pub. Date : 1991 Nov

PMID : 1655977






3 Functional Relationships(s)
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1 In the rat pineal gland, alpha 1-adrenergic agonists, which stimulate arachidonic acid release, also potentiate vasoactive intestinal peptide (VIP)- or beta-adrenergic-stimulated cyclic AMP (cAMP) and cyclic GMP (cGMP) accumulation. Arachidonic Acid vasoactive intestinal peptide Rattus norvegicus
2 Taken together, these findings indicate that the arachidonic acid cascade is likely involved in the alpha 1-adrenergic potentiation of VIP- or beta-adrenergic-stimulated cAMP and cGMP accumulation. Arachidonic Acid vasoactive intestinal peptide Rattus norvegicus
3 However, the specific arachidonic acid metabolite involved in the potentiation mechanisms of VIP- versus beta-adrenergic-stimulated cyclic nucleotide responses may be different. Arachidonic Acid vasoactive intestinal peptide Rattus norvegicus