Title : Phorbol ester-mediated inhibition of IFN-alpha/beta gene transcription in blood mononuclear leukocytes.

Pub. Date : 1991 Nov 1

PMID : 1655906






3 Functional Relationships(s)
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1 The phorbol ester PMA efficiently inhibits the in vitro IFN-alpha and -beta responses in human blood monocytes induced by Sendai virus and in natural IFN-producing cells induced by glutaraldehyde-fixed herpes simplex virus-infected human amnion (WISH) cells. Tetradecanoylphorbol Acetate interferon alpha 1 Homo sapiens
2 The synthetic diacylglycerol 1-oleoyl-2-acetylglycerol has the same effects as PMA, and the protein kinase inhibitor staurosporine prevents the PMA-mediated inhibition of IFN-alpha/beta expression. Tetradecanoylphorbol Acetate interferon alpha 1 Homo sapiens
3 The synthetic diacylglycerol 1-oleoyl-2-acetylglycerol has the same effects as PMA, and the protein kinase inhibitor staurosporine prevents the PMA-mediated inhibition of IFN-alpha/beta expression. Tetradecanoylphorbol Acetate interferon alpha 1 Homo sapiens