Title : Quantification of benzo[a]pyrene diol epoxide DNA-adducts by stable isotope dilution liquid chromatography/tandem mass spectrometry.

Pub. Date : 2006

PMID : 16557497






1 Functional Relationships(s)
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1 Further CYP1A1- and/or CYP1B1-mediated activation of the dihydrodiol results in the formation of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (B[a]PDE), the ultimate carcinogen. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide cytochrome P450 family 1 subfamily A member 1 Homo sapiens