Title : Binding of tissue inhibitor of metalloproteinases 2 to two distinct sites on human 72-kDa gelatinase. Identification of a stabilization site.

Pub. Date : 1991 Sep 25

PMID : 1655733






6 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Incubation of 125I-TIMP-2 with 72-kDa progelatinase-TIMP-2 complexes resulted in a concentration-dependent exchange of labeled TIMP-2 with unlabeled TIMP-2, in both the presence and absence of the metalloproteinase inhibitor 1,10-phenanthroline. 1,10-phenanthroline TIMP metallopeptidase inhibitor 2 Homo sapiens
2 Incubation of 125I-TIMP-2 with 72-kDa progelatinase-TIMP-2 complexes resulted in a concentration-dependent exchange of labeled TIMP-2 with unlabeled TIMP-2, in both the presence and absence of the metalloproteinase inhibitor 1,10-phenanthroline. 1,10-phenanthroline TIMP metallopeptidase inhibitor 2 Homo sapiens
3 Incubation of 125I-TIMP-2 with 72-kDa progelatinase-TIMP-2 complexes resulted in a concentration-dependent exchange of labeled TIMP-2 with unlabeled TIMP-2, in both the presence and absence of the metalloproteinase inhibitor 1,10-phenanthroline. 1,10-phenanthroline TIMP metallopeptidase inhibitor 2 Homo sapiens
4 Incubation of 125I-TIMP-2 with 72-kDa progelatinase-TIMP-2 complexes resulted in a concentration-dependent exchange of labeled TIMP-2 with unlabeled TIMP-2, in both the presence and absence of the metalloproteinase inhibitor 1,10-phenanthroline. 1,10-phenanthroline TIMP metallopeptidase inhibitor 2 Homo sapiens
5 Binding of 125I-TIMP-2 to the active site was completely inhibited by 1,10-phenanthroline. 1,10-phenanthroline TIMP metallopeptidase inhibitor 2 Homo sapiens
6 In the presence of 1,10-phenanthroline, 72-kDa progelatinase bound 125I-TIMP-2 but not 125I-TIMP-1. 1,10-phenanthroline TIMP metallopeptidase inhibitor 2 Homo sapiens