Pub. Date : 1991 Sep
PMID : 1655330
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Plasma and tissue kallikrein-kinin systems during acute administration of frusemide in normotensive and hypertensive humans. | Furosemide | kallikrein related peptidase 4 | Homo sapiens |
| 2 | Frusemide increased plasma pre-kallikrein, angiotensin II and aldosterone concentrations and plasma renin activity, whereas the plasma level of tissue kallikrein remained unchanged. | Furosemide | kallikrein related peptidase 4 | Homo sapiens |
| 3 | Frusemide increased the urine volume and the excretion of Na+, K+, Mg2+, Cl-, aldosterone, prostaglandin E2 and tissue kallikrein. | Furosemide | kallikrein related peptidase 4 | Homo sapiens |
| 4 | Thus, acute administration of frusemide to hypertensive patients and normal subjects increased the plasma level of pre-kallikrein, possibly indicating less activation to kallikrein and subsequently less kinin generation in the blood stream. | Furosemide | kallikrein related peptidase 4 | Homo sapiens |
| 5 | Thus, acute administration of frusemide to hypertensive patients and normal subjects increased the plasma level of pre-kallikrein, possibly indicating less activation to kallikrein and subsequently less kinin generation in the blood stream. | Furosemide | kallikrein related peptidase 4 | Homo sapiens |
| 6 | Urinary excretion of kallikrein is reduced in patients with primary hypertension after the administration of frusemide, apparently without affecting the renal excretory response. | Furosemide | kallikrein related peptidase 4 | Homo sapiens |